Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC2367521 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Lee Seungmook S Jhun Mina M Lee Eun-Kyung EK Park Taesung T
BMC proceedings 20071218
Understanding the genetic basis of human variation is an important goal of biomedical research. In this study, we used structural equation models (SEMs) to construct genetic networks to model how specific single-nucleotide polymorphisms (SNPs) from two genes known to cause acute myeloid leukemia (AML) by somatic mutation, runt-related transcription factor 1 (RUNX1) and ets variant gene 6 (ETV6), affect expression levels of other genes and how RUNX1 and ETV6 are related to each other. The SEM app ...[more]