Ontology highlight
ABSTRACT:
SUBMITTER: Cevec M
PROVIDER: S-EPMC2367737 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Cevec Mirko M Thibaudeau Christophe C Plavec Janez J
Nucleic acids research 20080222 7
Let-7 microRNA (miRNA) regulates heterochronic genes in developmental timing of the nematode Caenorhabditis elegans. Binding of miRNA to messenger RNA (mRNA) and structural features of the complex are crucial for gene silencing. We herein present the NMR solution structure of a model mimicking the interaction of let-7 miRNA with its complementary site (LCS 2) in the 3' untranslated region (3'-UTR) of the lin-41 mRNA. A structural study was performed by NMR spectroscopy using NOE restraints, tors ...[more]