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ABSTRACT:
SUBMITTER: Chattopadhyay MK
PROVIDER: S-EPMC2373341 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Chattopadhyay Manas K MK Park Myung Hee MH Tabor Herbert H
Proceedings of the National Academy of Sciences of the United States of America 20080501 18
Spermidine and its derivative, hypusinated eIF5A, are essential for the growth of Saccharomyces cerevisiae. Very low concentrations of spermidine (10(-8) M) are sufficient for the growth of S. cerevisiae polyamine auxotrophs (spe1Delta, spe2Delta, and spe3Delta). Under these conditions, even though the growth rate is near normal, the internal concentration of spermidine is <0.2% of the spermidine concentration present in wild-type cells. When spe2Delta cells are grown with low concentrations of ...[more]