Ontology highlight
ABSTRACT:
SUBMITTER: Schrag JD
PROVIDER: S-EPMC2373355 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Schrag Joseph D JD Jiralerspong Sarn S Banville Myriam M Jaramillo Maria Luz ML O'Connor-McCourt Maureen D MD
Proceedings of the National Academy of Sciences of the United States of America 20080429 18
Gadd45 proteins are recognized as tumor and autoimmune suppressors whose expression can be induced by genotoxic stresses. These proteins are involved in cell cycle control, growth arrest, and apoptosis through interactions with a wide variety of binding partners. We report here the crystal structure of Gadd45gamma, which reveals a fold comprising an alphabetaalpha sandwich with a central five-stranded mixed beta-sheet with alpha-helices packed on either side. Based on crystallographic symmetry w ...[more]