Ontology highlight
ABSTRACT:
SUBMITTER: Lacalle RA
PROVIDER: S-EPMC2373511 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Lacalle Rosa Ana RA Peregil Rosa M RM Albar Juan Pablo JP Merino Ernesto E Martínez-A Carlos C Mérida Isabel I Mañes Santos S
The Journal of cell biology 20071224 7
Directional cell movement in response to external chemical gradients requires establishment of front-rear asymmetry, which distinguishes an up-gradient protrusive leading edge, where Rac-induced F-actin polymerization takes place, and a down-gradient retractile tail (uropod in leukocytes), where RhoA-mediated actomyosin contraction occurs. The signals that govern this spatial and functional asymmetry are not entirely understood. We show that the human type I phosphatidylinositol 4-phosphate 5-ki ...[more]