Ontology highlight
ABSTRACT:
SUBMITTER: Carulla N
PROVIDER: S-EPMC2373618 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Carulla Natàlia N Woodward Clare C Barany George G
Protein science : a publication of the Protein Society 20020601 6
BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM ...[more]