Ontology highlight
ABSTRACT:
SUBMITTER: Copley RR
PROVIDER: S-EPMC2373934 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20010201 2
Sequence similarity is the most common measure currently used to infer homology between proteins. Typically, homologous protein domains show sequence similarity over their entire lengths. Here we identify Asp box motifs, initially found as repeats in sialidases and neuraminidases, in new structural and sequence contexts. These motifs represent significantly similar sequences, localized to beta hairpins within proteins that are otherwise different in sequence and three-dimensional structure. By p ...[more]