Ontology highlight
ABSTRACT:
SUBMITTER: Andreeva NS
PROVIDER: S-EPMC2374050 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20011201 12
To elucidate the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymes, we analyzed and compared the crystal structures of these enzymes, their complexes with inhibitors, and zymogens in the active site area (a total of 82 structures). In addition to the water molecule (W1) located between the active carboxyls and playing a role of the nucleophile during catalytic reaction, another water molecule (W2) at the vicinity of the active groups was found to be completely con ...[more]