Ontology highlight
ABSTRACT:
SUBMITTER: Lejon S
PROVIDER: S-EPMC2374170 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Lejon Sara S Cramer Jacob Flyvholm JF Nordberg Peter P
Acta crystallographica. Section F, Structural biology and crystallization communications 20080118 Pt 2
The previously determined crystal structure of the bacterial albumin-binding GA module in complex with human serum albumin (HSA) suggested the possibility of utilizing the complex in the study of ligand binding to HSA. As a continuation of these studies, the crystal structure of the HSA-GA complex with the drug molecule naproxen and the fatty acid decanoate bound to HSA has been determined to a resolution of 2.5 A. In terms of drug binding, the structure suggests that the binding of decanoate to ...[more]