Model-based analysis of two-color arrays (MA2C).
Ontology highlight
ABSTRACT:
SUBMITTER: Song JS
PROVIDER: S-EPMC2375008 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Model-based analysis of two-color arrays (MA2C).
Song Jun S JS Johnson W Evan WE Zhu Xiaopeng X Zhang Xinmin X Li Wei W Manrai Arjun K AK Liu Jun S JS Chen Runsheng R Liu X Shirley XS
Genome biology 20070101 8
A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates of the model parameters, is shown to perform superbly on published data sets. A robust algorithm for detecting peak regions is also formulated and shown to perform well compared to other approaches. The tools have been implemented as a stand-alone Java program called MA2C, which can display various plots of statistical analysis for quality c ...[more]
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