Ontology highlight
ABSTRACT:
SUBMITTER: Rencus-Lazar S
PROVIDER: S-EPMC2375110 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
PloS one 20080521 5
Int6 is a proto-oncogene implicated in various types of cancer, but the mechanisms underlying its activity are not clear. Int6 encodes a subunit of the eukaryotic translation initiation factor 3, and interacts with two related complexes, the proteasome, whose activity is regulated by Int6 in S. pombe, and the COP9 signalosome. The COP9 signalosome regulates the activity of Cullin-Ring Ubiquitin Ligases via deneddylation of their cullin subunit. We report here the generation and analysis of two D ...[more]