Applications for ROCK kinase inhibition.
Ontology highlight
ABSTRACT:
SUBMITTER: Olson MF
PROVIDER: S-EPMC2377343 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
Applications for ROCK kinase inhibition.
Current opinion in cell biology 20080220 2
ROCK kinases, which play central roles in the organization of the actin cytoskeleton, are tantalizing targets for the treatment of human diseases. Deletion of ROCK I in mice revealed a role in the pathophysiological responses to high blood pressure, and validated ROCK inhibition for the treatment of specific types of cardiovascular disease. To date, the only ROCK inhibitor employed clinically in humans is fasudil, which has been used safely in Japan since 1995 for the treatment of cerebral vasos ...[more]
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