Ontology highlight
ABSTRACT:
SUBMITTER: Davis BR
PROVIDER: S-EPMC2384133 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Davis Brian R BR Dicola Michael J MJ Prokopishyn Nicole L NL Rosenberg Jonathan B JB Moratto Daniele D Muul Linda M LM Candotti Fabio F Michael Blaese R R
Blood 20080310 10
Spontaneous somatic reversions of inherited mutations are poorly understood phenomena that are thought to occur uncommonly in a variety of genetic disorders. When molecularly characterized, revertant cells have rarely exhibited more than one revertant genotype per patient. We analyzed individual allospecific T-cell clones derived from a Wiskott-Aldrich syndrome (WAS) patient identified by flow cytometry to have 10% to 15% revertant, WAS protein-expressing lymphocytes in his blood. Genotypic anal ...[more]