Ontology highlight
ABSTRACT:
SUBMITTER: Berno V
PROVIDER: S-EPMC2386239 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Berno Valeria V Amazit Larbi L Hinojos Cruz C Zhong Jeannie J Mancini Maureen G MG Sharp Zelton Dave ZD Mancini Michael A MA
PloS one 20080528 5
Estrogen receptor-alpha (ER) transcription function is regulated in a ligand-dependent (e.g., estradiol, E2) or ligand-independent (e.g., growth factors) manner. Our laboratory seeks to understand these two modes of action. Using a cell line that contains a visible prolactin enhancer/promoter array (PRL-HeLa) regulated by ER, we analyzed ER response to E2 and EGF by quantifying image-based results. Data show differential recruitment of GFP-ER to the array, with the AF1 domain playing a vital rol ...[more]