Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC2386434 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Liu Hongbo H Abramczyk Dariusz D Cooper Chester R CR Zheng Li L Park Changwon C Szaniszlo Paul J PJ
Fungal genetics and biology : FG & B 20071022 5
The general transcriptional repressor Tup1p is known to influence cell development in many fungi. To determine whether the Tup1p ortholog (WdTup1p) of Wangiella dermatitidis also influences cellular development in this melanized, polymorphic human pathogen, the gene (WdTUP1) that encodes this transcription factor was isolated, sequenced and disrupted. Phylogenetic analysis showed that the WdTup1p sequence was closely related to homologues in other polymorphic, conidiogenous fungi. Disruption of ...[more]