Ontology highlight
ABSTRACT:
SUBMITTER: Taveggia C
PROVIDER: S-EPMC2387056 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Taveggia Carla C Zanazzi George G Petrylak Ashley A Yano Hiroko H Rosenbluth Jack J Einheber Steven S Xu Xiaorong X Esper Raymond M RM Loeb Jeffrey A JA Shrager Peter P Chao Moses V MV Falls Douglas L DL Role Lorna L Salzer James L JL
Neuron 20050901 5
The signals that determine whether axons are ensheathed or myelinated by Schwann cells have long been elusive. We now report that threshold levels of neuregulin-1 (NRG1) type III on axons determine their ensheathment fate. Ensheathed axons express low levels whereas myelinated fibers express high levels of NRG1 type III. Sensory neurons from NRG1 type III deficient mice are poorly ensheathed and fail to myelinate; lentiviral-mediated expression of NRG1 type III rescues these defects. Expression ...[more]