Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.
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ABSTRACT:
SUBMITTER: Haldar MK
PROVIDER: S-EPMC2390822 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
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Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.
Haldar Manas K MK Scott Michael D MD Sule Nitesh N Srivastava D K DK Mallik Sanku S
Bioorganic & medicinal chemistry letters 20080304 7
The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency. ...[more]
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