Ontology highlight
ABSTRACT:
SUBMITTER: Cirrito JR
PROVIDER: S-EPMC2390913 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Neuron 20080401 1
Aggregation of amyloid-beta (Abeta) peptide into soluble and insoluble forms within the brain extracellular space is central to the pathogenesis of Alzheimer's disease. Full-length amyloid precursor protein (APP) is endocytosed from the cell surface into endosomes where it is cleaved to produce Abeta. Abeta is subsequently released into the brain interstitial fluid (ISF). We hypothesized that synaptic transmission results in more APP endocytosis, thereby increasing Abeta generation and release i ...[more]