Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC2390926 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Wu Ximei X Tu Xiaolin X Joeng Kyu Sang KS Hilton Matthew J MJ Williams David A DA Long Fanxin F
Cell 20080401 2
Canonical Wnt signaling critically regulates cell fate and proliferation in development and disease. Nuclear localization of beta-catenin is indispensable for canonical Wnt signaling; however, the mechanisms governing beta-catenin nuclear localization are not well understood. Here we demonstrate that nuclear accumulation of beta-catenin in response to Wnt requires Rac1 activation. The role of Rac1 depends on phosphorylation of beta-catenin at Ser191 and Ser605, which is mediated by JNK2 kinase. ...[more]