Ontology highlight
ABSTRACT:
SUBMITTER: Wildman SS
PROVIDER: S-EPMC2390963 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Wildman Scott S P SS Marks Joanne J Turner Clare M CM Yew-Booth Liang L Peppiatt-Wildman Claire M CM King Brian F BF Shirley David G DG Wang Wenhui W Unwin Robert J RJ
Journal of the American Society of Nephrology : JASN 20080130 4
The epithelial sodium channel (ENaC) plays a major role in the regulation of sodium balance and BP by controlling Na(+) reabsorption along the renal distal tubule and collecting duct (CD). ENaC activity is affected by extracellular nucleotides acting on P2 receptors (P2R); however, there remain uncertainties over the P2R subtype(s) involved, the molecular mechanism(s) responsible, and their physiologic role. This study investigated the relationship between apical P2R and ENaC activity by assessi ...[more]