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The peroxiredoxin repair proteins.


ABSTRACT: Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry.

SUBMITTER: Jonsson TJ 

PROVIDER: S-EPMC2391273 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature

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The peroxiredoxin repair proteins.

Jönsson Thomas J TJ   Lowther W Todd WT  

Sub-cellular biochemistry 20070101


Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry. ...[more]

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2019-10-16 | GSE138846 | GEO