Ontology highlight
ABSTRACT:
SUBMITTER: Jonsson TJ
PROVIDER: S-EPMC2391273 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Jönsson Thomas J TJ Lowther W Todd WT
Sub-cellular biochemistry 20070101
Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry. ...[more]