Ontology highlight
ABSTRACT:
SUBMITTER: Bahram S
PROVIDER: S-EPMC23944 | biostudies-literature | 1999 Nov
REPOSITORIES: biostudies-literature
Bahram S S Gilfillan S S Kühn L C LC Moret R R Schulze J B JB Lebeau A A Schümann K K
Proceedings of the National Academy of Sciences of the United States of America 19991101 23
The puzzling linkage between genetic hemochromatosis and histocompatibility loci became even more so when the gene involved, HFE, was identified. Indeed, within the well defined, mainly peptide-binding, MHC class I family of molecules, HFE seems to perform an unusual yet essential function. As yet, our understanding of HFE function in iron homeostasis is only partial; an even more open question is its possible role in the immune system. To advance on both of these avenues, we report the deletion ...[more]