High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae.

ABSTRACT: We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.

SUBMITTER: Lee HG 

PROVIDER: S-EPMC2395236 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature