CPSARST: an efficient circular permutation search tool applied to the detection of novel protein structural relationships.
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ABSTRACT:
SUBMITTER: Lo WC
PROVIDER: S-EPMC2395249 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
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CPSARST: an efficient circular permutation search tool applied to the detection of novel protein structural relationships.
Lo Wei-Cheng WC Lyu Ping-Chiang PC
Genome biology 20080118 1
Circular permutation of a protein can be visualized as if the original amino- and carboxyl termini were linked and new ones created elsewhere. It has been well-documented that circular permutants usually retain native structures and biological functions. Here we report CPSARST (Circular Permutation Search Aided by Ramachandran Sequential Transformation) to be an efficient database search tool. In this post-genomics era, when the amount of protein structural data is increasing exponentially, it p ...[more]
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