Ontology highlight
ABSTRACT:
SUBMITTER: Medler TR
PROVIDER: S-EPMC2396244 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Medler Terry R TR Petrusca Daniela N DN Lee Patty J PJ Hubbard Walter C WC Berdyshev Evgeny V EV Skirball Jarrett J Kamocki Krzysztof K Schuchman Edward E Tuder Rubin M RM Petrache Irina I
American journal of respiratory cell and molecular biology 20080110 6
The de novo pathway of ceramide synthesis has been implicated in the pathogenesis of excessive lung apoptosis and murine emphysema. Intracellular and paracellular-generated ceramides may trigger apoptosis and propagate the death signals to neighboring cells, respectively. In this study we compared the sphingolipid signaling pathways triggered by the paracellular- versus intracellular-generated ceramides as they induce lung endothelial cell apoptosis, a process important in emphysema development. ...[more]