Ontology highlight
ABSTRACT:
SUBMITTER: Molinier J
PROVIDER: S-EPMC2396500 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Molinier Jean J Lechner Esther E Dumbliauskas Eva E Genschik Pascal P
PLoS genetics 20080613 6
Plants use the energy in sunlight for photosynthesis, but as a consequence are exposed to the toxic effect of UV radiation especially on DNA. The UV-induced lesions on DNA affect both transcription and replication and can also have mutagenic consequences. Here we investigated the regulation and the function of the recently described CUL4-DDB1-DDB2 E3 ligase in the maintenance of genome integrity upon UV-stress using the model plant Arabidopsis. Physiological, biochemical, and genetic evidences i ...[more]