Ontology highlight
ABSTRACT:
SUBMITTER: Kippert A
PROVIDER: S-EPMC2396630 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Kippert Angelika A Trajkovic Katarina K Fitzner Dirk D Opitz Lennart L Simons Mikael M
BMC neuroscience 20080425
<h4>Background</h4>During the development of the central nervous system, oligodendrocytes generate large amounts of myelin, a multilayered insulating membrane that ensheathes axons, thereby allowing the fast conduction of the action potential and maintaining axonal integrity. Differentiation of oligodendrocytes to myelin-forming cells requires the downregulation of RhoA GTPase activity.<h4>Results</h4>To gain insights into the molecular mechanisms of oligodendrocyte differentiation, we performed ...[more]