Perturbational profiling of nanomaterial biologic activity.
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ABSTRACT:
SUBMITTER: Shaw SY
PROVIDER: S-EPMC2396702 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Publications
Perturbational profiling of nanomaterial biologic activity.
Shaw Stanley Y SY Westly Elizabeth C EC Pittet Mikael J MJ Subramanian Aravind A Schreiber Stuart L SL Weissleder Ralph R
Proceedings of the National Academy of Sciences of the United States of America 20080520 21
Our understanding of the biologic effects (including toxicity) of nanomaterials is incomplete. In vivo animal studies remain the gold standard; however, widespread testing remains impractical, and the development of in vitro assays that correlate with in vivo activity has proven challenging. Here, we demonstrate the feasibility of analyzing in vitro nanomaterial activity in a generalizable, systematic fashion. We assessed nanoparticle effects in a multidimensional manner, using multiple cell typ ...[more]
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