Ontology highlight
ABSTRACT:
SUBMITTER: Becker MN
PROVIDER: S-EPMC2397383 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Becker Marie N MN Obraztsova Maria M Kern Earl R ER Quenelle Debra C DC Keith Kathy A KA Prichard Mark N MN Luo Ming M Moyer Richard W RW
Virology journal 20080514
<h4>Background</h4>The emergence of drug resistant viruses, together with the possibility of increased virulence, is an important concern in the development of new antiviral compounds. Cidofovir (CDV) is a phosphonate nucleotide that is approved for use against cytomegalovirus retinitis and for the emergency treatment of smallpox or complications following vaccination. One mode of action for CDV has been demonstrated to be the inhibition of the viral DNA polymerase.<h4>Results</h4>We have isolat ...[more]