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Subplate neuron ablation alters neurotrophin expression and ocular dominance column formation.

ABSTRACT: Ocular dominance column formation in visual cortex depends on both the presence of subplate neurons and the endogenous expression of neurotrophins. Here we show that deletion of subplate neurons, which supply glutamatergic inputs to visual cortex, leads to a paradoxical increase in brain-derived neurotrophic factor mRNA in the same region of visual cortex in which ocular dominance columns are absent. Subplate neuron ablation also increases glutamic acid decarboxylase-67 levels, indicating an alteration in cortical inhibition. These observations imply a role for this special class of neurons in modulating activity-dependent competition by regulating levels of neurotrophins and excitability within a developing cortical circuit.

SUBMITTER: Lein ES

PROVIDER: S-EPMC23975 | biostudies-literature | 1999 Nov

REPOSITORIES: biostudies-literature

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Subplate neuron ablation alters neurotrophin expression and ocular dominance column formation.

Lein E S ES Finney E M EM McQuillen P S PS Shatz C J CJ

Proceedings of the National Academy of Sciences of the United States of America 19991101 23

Ocular dominance column formation in visual cortex depends on both the presence of subplate neurons and the endogenous expression of neurotrophins. Here we show that deletion of subplate neurons, which supply glutamatergic inputs to visual cortex, leads to a paradoxical increase in brain-derived neurotrophic factor mRNA in the same region of visual cortex in which ocular dominance columns are absent. Subplate neuron ablation also increases glutamic acid decarboxylase-67 levels, indicating an alt ...[more]

PMID: 10557348

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