Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments.
Ontology highlight
ABSTRACT:
SUBMITTER: Manikandan K
PROVIDER: S-EPMC2397504 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments.
Manikandan Karuppasamy K Pal Debnath D Ramakumar Suryanarayanarao S Brener Nathan E NE Iyengar Sitharama S SS Seetharaman Guna G
Genome biology 20080310 3
We have developed a geometric clustering algorithm using backbone phi,psi angles to group conformationally similar peptide fragments of any length. By labeling each fragment in the cluster with the level-specific Gene Ontology 'molecular function' term of its protein, we are able to compute statistics for molecular function-propensity and p-value of individual fragments in the cluster. Clustering-cum-statistical analysis for peptide fragments 8 residues in length and with only trans peptide bond ...[more]
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