Unknown

Dataset Information

0

Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex.


ABSTRACT: The Dystroglycan-Dystrophin (Dg-Dys) complex has a capacity to transmit information from the extracellular matrix to the cytoskeleton inside the cell. It is proposed that this interaction is under tight regulation; however the signaling/regulatory components of Dg-Dys complex remain elusive. Understanding the regulation of the complex is critical since defects in this complex cause muscular dystrophy in humans. To reveal new regulators of the Dg-Dys complex, we used a model organism Drosophila melanogaster and performed genetic interaction screens to identify modifiers of Dg and Dys mutants in Drosophila wing veins. These mutant screens revealed that the Dg-Dys complex interacts with genes involved in muscle function and components of Notch, TGF-beta and EGFR signaling pathways. In addition, components of pathways that are required for cellular and/or axonal migration through cytoskeletal regulation, such as Semaphorin-Plexin, Frazzled-Netrin and Slit-Robo pathways show interactions with Dys and/or Dg. These data suggest that the Dg-Dys complex and the other pathways regulating extracellular information transfer to the cytoskeletal dynamics are more intercalated than previously thought.

SUBMITTER: Kucherenko MM 

PROVIDER: S-EPMC2398783 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex.

Kucherenko Mariya M MM   Pantoja Mario M   Yatsenko Andriy S AS   Shcherbata Halyna R HR   Fischer Karin A KA   Maksymiv Dariya V DV   Chernyk Yaroslava I YI   Ruohola-Baker Hannele H  

PloS one 20080611 6


The Dystroglycan-Dystrophin (Dg-Dys) complex has a capacity to transmit information from the extracellular matrix to the cytoskeleton inside the cell. It is proposed that this interaction is under tight regulation; however the signaling/regulatory components of Dg-Dys complex remain elusive. Understanding the regulation of the complex is critical since defects in this complex cause muscular dystrophy in humans. To reveal new regulators of the Dg-Dys complex, we used a model organism Drosophila m  ...[more]

Similar Datasets

| S-EPMC3217851 | biostudies-literature
| S-SCDT-10_1038-S44319-024-00319-Y | biostudies-other
| S-EPMC8673539 | biostudies-literature
| S-EPMC6063225 | biostudies-literature
| S-EPMC7157587 | biostudies-literature
| S-EPMC3610854 | biostudies-literature
2023-01-12 | GSE222376 | GEO
| S-EPMC5257257 | biostudies-literature
| S-EPMC1770854 | biostudies-literature
| S-EPMC5738738 | biostudies-literature