Safety profile of L-arginine infusion in moderately severe falciparum malaria.

ABSTRACT:

Background

L-arginine infusion improves endothelial function in malaria but its safety profile has not been described in detail. We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine infusion in adults with moderately severe malaria.

Methodology and findings

In an ascending dose study, adjunctive intravenous L-arginine hydrochloride was infused over 30 minutes in doses of 3 g, 6 g and 12 g to three separate groups of 10 adults hospitalized with moderately severe Plasmodium falciparum malaria in addition to standard quinine therapy. Symptoms, vital signs and selected biochemical measurements were assessed before, during, and for 24 hours after infusion. No new or worsening symptoms developed apart from mild discomfor

SUBMITTER: Yeo TW 

PROVIDER: S-EPMC2405947 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature