Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC240671 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Zhang Zhongqiu Z Futamura Manabu M Vikis Haris G HG Wang Min M Li Jie J Wang Yian Y Guan Kun-Liang KL You Ming M
Proceedings of the National Academy of Sciences of the United States of America 20031001 22
Pulmonary adenoma susceptibility 1 (Pas1), located on chromosome 6, is the major locus affecting inherited predisposition to lung tumor development in mice. We have fine mapped the Pas1 locus to a region of approximately 0.5 megabases by using congenic strains of mice, constructed by placing the Pas1 region of chromosome 6 from A/J mice onto the genetic background of C57BL/6J mice. Systematic characterization of Pas1 candidates establishes the Las1 (lung adenoma susceptibility 1) and Kras2 (Kirs ...[more]