Ontology highlight
ABSTRACT:
SUBMITTER: Koelle DM
PROVIDER: S-EPMC240716 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Koelle David M DM Liu Zhi Z McClurkan Christopher L CL Cevallos Randal C RC Vieira Jeffrey J Hosken Nancy A NA Meseda Clement A CA Snow Devon C DC Wald Anna A Corey Lawrence L
Proceedings of the National Academy of Sciences of the United States of America 20031017 22
The study of immunodominance within microbe-specific CD8 T cell responses has been challenging. We used a previously undescribed approach to create unbiased panels of CD8 cytotoxic T lymphocyte clones specific for herpes simplex virus type 2, a pathogen with a complex genome encoding at least 85 polypeptides. Circulating herpes simplex virus type 2-specific cells were enriched and cloned after sorting for expression of the skin homing-associated receptor, cutaneous lymphocyte-associated antigen, ...[more]