Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor.
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ABSTRACT:
SUBMITTER: Rimon E
PROVIDER: S-EPMC2408813 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
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Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor.
Rimon Eli E Chen Baosheng B Shanks Anthony L AL Nelson D Michael DM Sadovsky Yoel Y
Endocrinology 20080221 6
The mechanisms underlying cellular injury when human placental trophoblasts are exposed to hypoxia are unclear. Connective tissue growth factor (CTGF) mediates cell injury and fibrosis in diverse tissues. We hypothesized that hypoxia enhances the production of CTGF in primary term human trophoblasts. Using cultured term primary human trophoblasts as well as villous biopsies from term human placentas, we showed that CTGF protein is expressed in trophoblasts. When compared with cells cultured in s ...[more]
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