Ontology highlight
ABSTRACT:
SUBMITTER: Beyer AM
PROVIDER: S-EPMC2408877 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Beyer Andreas M AM Baumbach Gary L GL Halabi Carmen M CM Modrick Mary L ML Lynch Cynthia M CM Gerhold Thomas D TD Ghoneim Shams M SM de Lange Willem J WJ Keen Henry L HL Tsai Yau-Sheng YS Maeda Nobuyo N Sigmund Curt D CD Faraci Frank M FM
Hypertension (Dallas, Tex. : 1979) 20080219 4
The transcription factor PPARgamma is expressed in endothelium and vascular muscle where it may exert antiinflammatory and antioxidant effects. We tested the hypothesis that PPARgamma plays a protective role in the vasculature by examining vascular structure and function in heterozygous knockin mice expressing the P465L dominant negative mutation in PPARgamma (L/+). In L/+ aorta, responses to the endothelium-dependent agonist acetylcholine (ACh) were not affected, but there was an increase in co ...[more]