Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.
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ABSTRACT:
SUBMITTER: Wellen KE
PROVIDER: S-EPMC2408881 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.
Wellen Kathryn E KE Fucho Raquel R Gregor Margaret F MF Furuhashi Masato M Morgan Carlos C Lindstad Torstein T Vaillancourt Eric E Gorgun Cem Z CZ Saatcioglu Fahri F Hotamisligil Gökhan S GS
Cell 20070501 3
Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead to metabolic dysregulation under conditions of chronic stress. Thus, we hypothesized that mechanisms might exist to prevent overt inflammatory responses during physiological fluctuations in nutrients or under nutrient-rich conditions, and we identified the six-transmembrane protein STAMP2 as a critical modulator of this integrated response system of ...[more]
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