Ontology highlight
ABSTRACT:
SUBMITTER: Prins KW
PROVIDER: S-EPMC2409075 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Prins Kurt W KW Lowe Dawn A DA Ervasti James M JM
PloS one 20080611 6
We previously documented a ten-fold increase in gamma(cyto)-actin expression in dystrophin-deficient skeletal muscle and hypothesized that increased gamma(cyto)-actin expression may participate in an adaptive cytoskeletal remodeling response. To explore whether increased gamma(cyto)-actin fortifies the cortical cytoskeleton in dystrophic skeletal muscle, we generated double knockout mice lacking both dystrophin and gamma(cyto)-actin specifically in skeletal muscle (ms-DKO). Surprisingly, dystrop ...[more]