Ontology highlight
ABSTRACT:
SUBMITTER: Krishna S
PROVIDER: S-EPMC2409224 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Krishna Sandeep S Semsey Szabolcs S Sneppen Kim K
Proceedings of the National Academy of Sciences of the United States of America 20071219 52
We analyze the connection between structure and function for regulatory motifs associated with cellular uptake and usage of small molecules. Based on the boolean logic of the feedback we suggest four classes: the socialist, consumer, fashion, and collector motifs. We find that the socialist motif is good for homeostasis of a useful but potentially poisonous molecule, whereas the consumer motif is optimal for nutrition molecules. Accordingly, examples of these motifs are found in, respectively, t ...[more]