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ABSTRACT:
SUBMITTER: Suzuki S
PROVIDER: S-EPMC2409257 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Suzuki Shiro S Yamamura Masaomi M Hattori Takefumi T Nakatsubo Tomoyuki T Umezawa Toshiaki T
Proceedings of the National Academy of Sciences of the United States of America 20071219 52
The selective formation of E- or Z-isomers is an important process in natural product metabolism. We show that the subunit composition of an enzyme can alter the geometrical composition of the enzymatic products. Hinokiresinol synthase, purified from Asparagus officinalis cell cultures, is responsible for the conversion of (7E,7'E)-4-coumaryl 4-coumarate to (Z)-hinokiresinol, the first step in norlignan formation. The protein is most likely a heterodimer composed of two distinct subunits, which ...[more]