Ontology highlight
ABSTRACT:
SUBMITTER: Xue M
PROVIDER: S-EPMC2409395 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Xue Mingshan M Stradomska Alicja A Chen Hongmei H Brose Nils N Zhang Weiqi W Rosenmund Christian C Reim Kerstin K
Proceedings of the National Academy of Sciences of the United States of America 20080527 22
Complexins (Cplxs) are key regulators of synaptic exocytosis, but whether they act as facilitators or inhibitors is currently being disputed controversially. We show that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca(2+)-triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses. Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhi ...[more]