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Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei.

ABSTRACT: The farnesyl diphosphate synthase (FPPS) has previously been characterized in trypanosomes as an essential enzyme for their survival and as the target for bisphosphonates, drugs that are effective both in vitro and in vivo against these parasites. Enzymes from the isoprenoid pathway have been assigned to different compartments in eukaryotes, including trypanosomatids. We here report that FPPS localizes to the cytoplasm of both Trypanosoma cruzi and T. brucei, and is not present in other organelles such as the mitochondria and glycosomes.

SUBMITTER: Ferella M 

PROVIDER: S-EPMC2409970 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei.

Ferella Marcela M   Li Zhu-Hong ZH   Andersson Björn B   Docampo Roberto R  

Experimental parasitology 20080313 2

The farnesyl diphosphate synthase (FPPS) has previously been characterized in trypanosomes as an essential enzyme for their survival and as the target for bisphosphonates, drugs that are effective both in vitro and in vivo against these parasites. Enzymes from the isoprenoid pathway have been assigned to different compartments in eukaryotes, including trypanosomatids. We here report that FPPS localizes to the cytoplasm of both Trypanosoma cruzi and T. brucei, and is not present in other organell  ...[more]

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