Ontology highlight
ABSTRACT:
SUBMITTER: Cheung HC
PROVIDER: S-EPMC2410136 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Cheung Hannah C HC Baggerly Keith A KA Tsavachidis Spiridon S Bachinski Linda L LL Neubauer Valerie L VL Nixon Tamara J TJ Aldape Kenneth D KD Cote Gilbert J GJ Krahe Ralf R
BMC genomics 20080512
<h4>Background</h4>Tumor-predominant splice isoforms were identified during comparative in silico sequence analysis of EST clones, suggesting that global aberrant alternative pre-mRNA splicing may be an epigenetic phenomenon in cancer. We used an exon expression array to perform an objective, genome-wide survey of glioma-specific splicing in 24 GBM and 12 nontumor brain samples. Validation studies were performed using RT-PCR on glioma cell lines, patient tumor and nontumor brain samples.<h4>Resu ...[more]