Ontology highlight
ABSTRACT:
SUBMITTER: Chisholm KM
PROVIDER: S-EPMC2413294 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Chisholm Karen M KM Goff Barbara A BA Garcia Rochelle R King Mary-Claire MC Swisher Elizabeth M EM
Cancer genetics and cytogenetics 20080501 1
The aim of this study was to determine the genomic structure of the deletions on chromosome 17 in ovarian carcinomas from women with inherited BRCA1 mutations. Normal and tumor DNA from 14 ovarian tumors associated with inherited BRCA1 mutations were extracted and tested for loss of heterozygosity (LOH) at microsatellite markers along chromosome 17. Finer mapping using more microsatellite markers and single nucleotide polymorphisms helped further define the LOH margins. The genomic repeated elem ...[more]