Ontology highlight
ABSTRACT:
SUBMITTER: Kim HR
PROVIDER: S-EPMC2414309 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Kim Hyung-Ryong HR Lee Geum-Hwa GH Ha Ki-Chan KC Ahn Taeho T Moon Ji-Yong JY Lee Bong-Jin BJ Cho Ssang-Goo SG Kim Sanguk S Seo Young-Rok YR Shin Yong-Joo YJ Chae Soo-Wan SW Reed John C JC Chae Han-Jung HJ
The Journal of biological chemistry 20080331 23
In this study, Bax inhibitor-1 (BI-1) overexpression reduces the ER pool of Ca(2+) released by thapsigargin. Cells overexpressing BI-1 also showed lower intracellular Ca(2+) release induced by the Ca(2+) ionophore ionomycin as well as agonists of ryanodine receptors and inositol trisphosphate receptors. In contrast, cells expressing carboxyl-terminal deleted BI-1 (CDelta-BI-1 cells) displayed normal intracellular Ca(2+) mobilization. Basal Ca(2+) release rates from the ER were higher in BI-1-ove ...[more]