Ontology highlight
ABSTRACT:
SUBMITTER: Bendjennat M
PROVIDER: S-EPMC2417159 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Bendjennat Mourad M Weil P Anthony PA
The Journal of biological chemistry 20080114 13
Essentially all nuclear eukaryotic gene transcription depends upon the function of the transcription factor TATA-binding protein (TBP). Here we show that the abundant, multifunctional DNA binding transcription factor repressor activator protein Rap1p interacts directly with TBP. TBP-Rap1p binding occurs efficiently in vivo at physiological expression levels, and in vitro analyses confirm that this is a direct interaction. The DNA binding domains of the two proteins mediate interaction between TB ...[more]