Ontology highlight
ABSTRACT:
SUBMITTER: Narasimhan J
PROVIDER: S-EPMC2423249 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Narasimhan Jana J Joyce Bradley R BR Naguleswaran Arunasalam A Smith Aaron T AT Livingston Meredith R MR Dixon Stacy E SE Coppens Isabelle I Wek Ronald C RC Sullivan William J WJ
The Journal of biological chemistry 20080416 24
A key problem in the treatment of numerous pathogenic eukaryotes centers on their development into latent forms during stress. For example, the opportunistic protist Toxoplasma gondii converts to latent cysts (bradyzoites) responsible for recrudescence of disease. We report that Toxoplasma eukaryotic initiation factor-2alpha (TgIF2alpha) is phosphorylated during stress and establish that protozoan parasites utilize translation control to modulate gene expression during development. Importantly, ...[more]