Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharya S
PROVIDER: S-EPMC2423268 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Bhattacharya Shibani S Zhang Hongtao H Debnath Asim K AK Cowburn David D
The Journal of biological chemistry 20080416 24
The human immunodeficiency virus type 1 (HIV-1) capsid protein plays a critical role in virus core particle assembly and is an important target for novel therapeutic strategies. In a previous study, we characterized the binding affinity of a hydrocarbon stapled helical peptide, NYAD-1, for the capsid protein (K(d) approximately 1 mum) and demonstrated its ability to penetrate the cell membrane (Zhang, H., Zhao, Q., Bhattacharya, S., Waheed, A. A., Tong, X., Hong, A., Heck, S., Goger, M., Cowburn ...[more]