Ontology highlight
ABSTRACT:
SUBMITTER: Bryk R
PROVIDER: S-EPMC2423947 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Bryk Ruslana R Gold Benjamin B Venugopal Aditya A Singh Jasbir J Samy Raghu R Pupek Krzysztof K Cao Hua H Popescu Carmen C Gurney Mark M Hotha Srinivas S Cherian Joseph J Rhee Kyu K Ly Lan L Converse Paul J PJ Ehrt Sabine S Vandal Omar O Jiang Xiuju X Schneider Jean J Lin Gang G Nathan Carl C
Cell host & microbe 20080301 3
Antibiotics are typically more effective against replicating rather than nonreplicating bacteria. However, a major need in global health is to eradicate persistent or nonreplicating subpopulations of bacteria such as Mycobacterium tuberculosis (Mtb). Hence, identifying chemical inhibitors that selectively kill bacteria that are not replicating is of practical importance. To address this, we screened for inhibitors of dihydrolipoamide acyltransferase (DlaT), an enzyme required by Mtb to cause tub ...[more]